Chemical Structure : PF-04957325
CAS No.:
1305115-80-3
PF-04957325
(PF 04957325)
Catalog No. : PC-38701Not For Human Use, Lab Use Only.
PF-04957325 is a highly potent and selective PDE8 inhibitor with IC50 values of 0.7 nM and 0.3 nM for PDE8A and PDE8B, respectively.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-3870101
Biological Activity
PF-04957325 is a highly potent and selective PDE8 inhibitor with IC50 values of 0.7 nM and 0.3 nM for PDE8A and PDE8B, respectively.
Physicochemical Properties
M.Wt
400.38
Formula
C14H15F3N8OS
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
3-[[(2R)-4-(2-Thiazolylmethyl)-2-morpholinyl]methyl]-5-(trifluoromethyl)-3H-1,2,3-triazolo[4,5-d]pyrimidin-7-amine
References
1. Tsai LC, et al. Mol Pharmacol.
2. Shimizu-Albergine M, et al. Mol Pharmacol
3. Dong H, et al. Breast Cancer Res Treat.
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