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Chemical Structure : PF-04957325
CAS No.: 1305115-80-3
Catalog No.: PC-38701Not For Human Use, Lab Use Only.
PF-04957325 is a highly potent and selective PDE8 inhibitor with IC50 values of 0.7 nM and 0.3 nM for PDE8A and PDE8B, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $248 | In stock | |
| 10 mg | $398 | In stock | |
| 25 mg | $598 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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PF-04957325 is a highly potent and selective PDE8 inhibitor with IC50 values of 0.7 nM and 0.3 nM for PDE8A and PDE8B, respectively.
PF-04957325 potentiates adrenocorticotropin stimulation of steroidogenesis by increasing cAMP-dependent protein kinase activity in both primary isolated adrenocortical cells and Y-1 cells.
PF-04957325 inhibits breast cancer cell migration by activation of cAMP signaling.
| M.Wt | 400.38 | |
| Formula | C14H15F3N8OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
3-[[(2R)-4-(2-Thiazolylmethyl)-2-morpholinyl]methyl]-5-(trifluoromethyl)-3H-1,2,3-triazolo[4,5-d]pyrimidin-7-amine |
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1. Tsai LC, et al. Mol Pharmacol. 2011 Apr;79(4):639-48.
2. Shimizu-Albergine M, et al. Mol Pharmacol. 2012 Apr;81(4):556-66.
3. Dong H, et al. Breast Cancer Res Treat. 2015 Jul;152(1):17-28.
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