Chemical Structure : PF-562271
CAS No.: 717907-75-0
Catalog No.: PC-42601Not For Human Use, Lab Use Only.
PF-562271 (VS-6062) is a potent, selective, ATP-competitive, reversible inhibitor of FAK and Pyk2 kinase with IC50 of 1.5 nM and 14 nM, respectively.
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| 5 mg | $58 | In stock | |
| 10 mg | $88 | In stock | |
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	PF-562271 (VS-6062) is a potent, selective, ATP-competitive, reversible inhibitor of FAK and Pyk2 kinase with IC50 of 1.5 nM and 14 nM, respectively.
	PF-562271 displayes robust inhibition in an inducible cell-based assay measuring phospho-FAK with IC50 of 5 nM.
	PF-562271 inhibits FAK phosphorylation in vivo in a dose-dependent fashion (EC50=93 ng/mL) after in tumor-bearing mice; orally bioavailable.
| M.Wt | 507.4888 | |
| Formula | C21H20F3N7O3S | |
| Appearance | Solid | |
| Storage | 
                            
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| Solubility | 
                             DMSO: ≥ 48 mg/mL  | 
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| Chemical Name/SMILES | 
                             Methanesulfonamide, N-[3-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]-2-pyridinyl]-N-methyl-  | 
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1. Roberts WG, et al. Cancer Res. 2008 Mar 15;68(6):1935-44.
2. Stokes JB, et al. Mol Cancer Ther. 2011 Nov;10(11):2135-45.
3. Slack-Davis JK, et al. Mol Cancer Ther. 2009 Aug;8(8):2470-7.

                
                
                
                
                
                
                
                
            
            
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