Chemical Structure : PF-562271
CAS No.:
717907-75-0
PF-562271
(VS-6062;PF-271;PF-00562271)
Catalog No. : PC-42601Not For Human Use, Lab Use Only.
PF-562271 (VS-6062) is a potent, selective, ATP-competitive, reversible inhibitor of FAK and Pyk2 kinase with IC50 of 1.5 nM and 14 nM, respectively.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-4260101
Biological Activity
PF-562271 (VS-6062) is a potent, selective, ATP-competitive, reversible inhibitor of FAK and Pyk2 kinase with IC50 of 1.5 nM and 14 nM, respectively.
Physicochemical Properties
M.Wt
507.4888
Formula
C21H20F3N7O3S
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
DMSO: ≥ 48 mg/mL
Chemical Name/SMILES
Methanesulfonamide, N-[3-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]-2-pyridinyl]-N-methyl-
References
1. Roberts WG, et al. Cancer Res
2. Stokes JB, et al. Mol Cancer Ther
3. Slack-Davis JK, et al. Mol Cancer Ther
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