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PF-719

Chemical Structure : PF-719

CAS No.: 1404454-02-9

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PF-719 (PF719)

Catalog No.: PC-22150Not For Human Use, Lab Use Only.

PF-719 (PF719) is a potent, selective Pyk2 inhibitor with IC50 of 17 nM, displays 25-fold selectvity over FAK (IC50=469 nM).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

PF-719 (PF719) is a potent, selective Pyk2 inhibitor with IC50 of 17 nM, displays 25-fold selectvity over FAK (IC50=469 nM).
PF-719 does not have significant inhibitory effects on recombinant MLCK2, p38, Akt1, or ROCK1, and very little inhibtion at Src family kinases (IC50>5 uM).
PF-719 selectively inhibits tyrosine phosphorylation of Pyk2 at 1 uM, but blocks both Pyk2 and FAK phosphorylation at 2.5 uM in A20 cells.
PF-719 reduces chemoattractant-induced migration of B-2 and MZ B cells.

Physicochemical Properties

M.Wt 448.49
Formula C22H27F3N6O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
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Solubility

10 mM in DMSO
Chemical Name/SMILES

N-cyclopropyl-4-(4-((1R,2R)-2-(dimethylamino)cyclopentylamino)-5-(trifluoromethyl)pyrimidin2-ylamino)benzamide

References

1. Tse KW, et al. Cell Immunol. 2012 Jan-Feb;275(1-2):47-54.

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