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Chemical Structure : PF 5212372
Catalog No.: PC-61846Not For Human Use, Lab Use Only.
PF 5212372 (PLA-950, ZPL-521, ZPL 5212372) is a potent, selective inhibitor of cPLA2 (cytosolic phospholipase A2α) with IC50 of 7 nM.
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PF 5212372 (PLA-950, ZPL-521, ZPL 5212372) is a potent, selective inhibitor of cPLA2 (cytosolic phospholipase A2α) with IC50 of 7 nM.
PF 5212372 inhibits PGD2 and cysteinyl leukotriene release from anti-IgE-stimulated human lung mast cells with IC50 of 0.29 and 0.45 nM, respectively.
PF 5212372 inhibits ionomycin-stimulated release of leukotriene B(4), thromboxane A(2), and PGD(2) (IC50 2.6, 2.6, and 4.0 nM, respectively).
PF 5212372 significantly inhibits AMP-induced contraction of human bronchi.
| M.Wt | 823.35 | |
| Formula | C42H38ClF3N2O6S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Hewson CA, et al. J Pharmacol Exp Ther. 2012 Mar;340(3):656-65.
2. McKew JC, et al. J Med Chem. 2008 Jun 26;51(12):3388-413.
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