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PI-701

Chemical Structure : PI-701

CAS No.: 2230715-18-9

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PI-701 (YM185453, PI 701)

Catalog No.: PC-23006Not For Human Use, Lab Use Only.

PI-701 (YM185453) is a selective inhibitor of class II PI3KC2β isoform with IC50 of 528 nM, does not display activity toward PI3K class I isoforms.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

PI-701 (YM185453) is a selective inhibitor of class II PI3KC2β isoform with IC50 of 528 nM, does not display activity toward PI3K class I isoforms.
PI-701 (YM185453) impaires proliferation of a panel of human cancer cell lines and primary cultures of acute myeloid leukemia (AML), glioblastoma multiforme (GBM), medulloblastoma (MB), neuroblastoma (NB), and small cell lung cancer (SCLC).
PI-701 (YM185453) induces apoptosis and sensitises cancer cells to chemotherapeutic agents.

Physicochemical Properties

M.Wt 553.64
Formula C30H27N5O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(4-morpholino-2-(3-(naphthalene-2-sulfonamido)phenyl)quinazolin-6-yl)acetamide

References

1. Boller D, et al. Anticancer Res. 2022 Jun;42(6):3217-3230.

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