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Chemical Structure : PI3Kα H1047R inhibitor 17
Catalog No.: PC-21947Not For Human Use, Lab Use Only.
PI3Kα H1047R inhibitor 17 is a potent, selective H1047R PI3Kα mutant inhibitor with IC50 of 1 nM (inhibition of pAKT formation), without effect on PI3Kα WT.
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PI3Kα H1047R inhibitor 17 is a potent, selective H1047R PI3Kα mutant inhibitor with IC50 of 1 nM (inhibition of pAKT formation), without effect on PI3Kα WT.
PI3Kα H1047R inhibitor 17 exhibits IC50 of 58 nM in viability assay in T47D (PI3KαH1047R), with low potency against SKBR3 (PI3KαWT) cell lines.
PI3Kα H1047R inhibitor 17 (00 mg/kg, IP, qd) causes tumor regressions in the HCC1954 tumor model in mice.
| M.Wt | 364.45 | |
| Formula | C22H24N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ketcham JM, et al. J Med Chem. 2024 Mar 13. doi: 10.1021/acs.jmedchem.4c00078.
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