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Chemical Structure : PLX5622
CAS No.: 1303420-67-8
Catalog No.: PC-62741Not For Human Use, Lab Use Only.
PLX5622 (PLX-5622) is a potent, selective, orally active inhibitor of CSF1R tyrosine kinase (c-Fms) activity with Ki of 5.9 nM, 60-fold less potency against KIT.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $158 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | $428 | In stock | |
| 100 mg | Get quote | ||
| 200 mg | Get quote | ||
| 1 g | Get quote |
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PLX5622 (PLX-5622) is a potent, selective, orally active inhibitor of CSF1R tyrosine kinase (c-Fms) activity with Ki of 5.9 nM, 60-fold less potency against KIT.
PLX5622 dispalys least 50-fold selectivity over 4 related kinases, and over 100-fold selectivity against a panel of 230 kinases.
PLX5622 prevents microglial plaque association and improves cognition in 3xTg-AD mice, also depletes microglia and alleviates the catatonic symptoms of Cnp mutants.
| M.Wt | 395.414 | |
| Formula | C21H19F2N5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
6-fluoro-N-((5-fluoro-2-methoxypyridin-3-yl)methyl)-5-((5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)pyridin-2-amine |
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1. Janova H, et al. J Clin Invest. 2018 Feb 1;128(2):734-745.
2. Spangenberg E, et al. Nat Commun. 2019 Aug 21;10(1):3758.
3. Dagher NN, et al. J Neuroinflammation. 2015 Aug 1;12:139.
4. Valdearcos M, et al. Cell Rep. 2014 Dec 24;9(6):2124-38.
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