PNU-183792 is a potent, non-nucleoside inhibitor of herpesviruses, specifically inhibit herpesvirus polymerases with IC50 of 0.69 uM, 0.37 uM and 0.58 uM for HCMV, varicella zoster virus (VZV) and herpes simplex virus (HSV) polymerases respectively.
PNU-183792 is inactive (IC(50) value >40 microM) against human alpha (alpha), gamma (gamma), or delta (delta) polymerases.
PNU-183792 has braod antiviral activity against both VZV (IC(50) value 0.1 microM) and HSV (IC(50) ranging from 3 to 5 microM) using plaque reduction assays.
PNU-183792 is also active (IC(50) ranging 0.1-0.7 microM) in cell culture assays against simian varicella virus (SVV), murine cytomegalovirus (MCMV) and rat cytomegalovirus (RCMV).
PNU-183792 is also active against both GCV-resistant and CDV-resistant HCMV and against ACV-resistant HSV.
PNU-183792 is inactive against unrelated DNA and RNA viruses indicating specificity for herpesviruses.
PNU-183792 orally bioavailable and was efficacious in a model of lethal MCMV infection.