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Chemical Structure : PNU-282987
CAS No.: 123464-89-1
Catalog No.: PC-43108Not For Human Use, Lab Use Only.
PNU-282987 is a potent, selective α7 nAChR agonist with Ki of 26 nM, shows negligible block of α1β1γδ and α3β4 nAChRs (IC50>60 uM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $118 | In stock | |
| 50 mg | $198 | In stock | |
| 100 mg | $358 | In stock | |
| 500 mg | Get quote | ||
| 1 g | Get quote |
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PNU-282987 is a potent, selective α7 nAChR agonist with Ki of 26 nM, shows negligible block of α1β1γδ and α3β4 nAChRs (IC50>60 uM).
PNU-282987 is inactive at all tested monoamine, muscarine, glutamate, and GABA receptors.
PNU-282987 evokes whole-cell currents from cultured rat hippocampal neurons, improves the inherent hippocampal gating deficit occurring in a subpopulation of anesthetized rats, and enhances amphetamine-induced hippocampal oscillation; enhances GABAergic synaptic activity in brain slices and restores auditory gating deficits in anesthetized rats.
| M.Wt | 301.2115 | |
| Formula | C14H18Cl2N2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 61 mg/mL |
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| Chemical Name/SMILES |
Benzamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chloro-, hydrochloride (1:1) |
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1. Hajós M, et al. J Pharmacol Exp Ther. 2005 Mar;312(3):1213-22.
2. Bodnar AL, et al. J Med Chem. 2005 Feb 24;48(4):905-8.
3. Su X, et al. Am J Respir Cell Mol Biol. 2007 Aug;37(2):186-92.
4. Hu M, et al. Brain Res. 2007 Jun 2;1151:227-35.
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