Chemical Structure : PRLthiophenib
CAS No.:
PRLthiophenib
Catalog No.: PC-25611Not For Human Use, Lab Use Only.
PRLthiophenib is a potent, selective inhibitor of phosphatase of regenerating liver 3 (PRL-3, PRL3) with IC50 of 7.8 uM, shows mucher weaker inhibitor for PRL-1 and -2 (IC50=31 uM and 15.8 uM), binds directly to PRL-3 with Kd of 23 uM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
PRLthiophenib is a potent, selective inhibitor of phosphatase of regenerating liver 3 (PRL-3, PRL3) with IC50 of 7.8 uM, shows mucher weaker inhibitor for PRL-1 and -2 (IC50=31 uM and 15.8 uM), binds directly to PRL-3 with Kd of 23 uM.
PRLthiophenib is selective over Vaccinia H1-related (VHR) phosphatas, protein tyrosine phosphatase 1B (PTP1B) and T cell protein tyrosine phosphatase (TCPTP).
PRLthiophenib rescues PRL-3-induced cell death in a three-dimensional PRL-3 expressing rescues PRL-3-induced mouse derived small intestine (SI) organoids.
Physicochemical Properties
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M.Wt
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447.51
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Formula
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C25H21NO5S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-Methylbenzyl (E)-3-(3-(5-acetylthiophen-2-yl)-4-hydroxy-5-methoxyphenyl)-2-cyanoacrylate
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References
1. Hoffmann A, et al. Bioorg Med Chem. 2025 Sep 23;131:118412.
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