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Chemical Structure : PRN694
Catalog No.: PC-35183Not For Human Use, Lab Use Only.
PRN694 (PRN-694) is a highly selective, potent, covalent inhibitor of interleukin-2-inducible T-cell kinase (ITK) and resting lymphocyte kinase (RLK) with IC50 of 0.3 and 1.4 nM, respectively.
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PRN694 (PRN-694) is a highly selective, potent, covalent inhibitor of interleukin-2-inducible T-cell kinase (ITK) and resting lymphocyte kinase (RLK) with IC50 of 0.3 and 1.4 nM, respectively.
PRN694 also potently inhibits family member TEC (IC50=3.3 nM), weakly inhibits BTK (IC50=17 nM), has no activity against EGFR, ERBB2 and ERBB4 in a panel of 250 kinases.
PRN694 prevents T-cell receptor- and Fc receptor-induced cellular and molecular activation, inhibits T-cell receptor-induced T-cell proliferation, and blocks proinflammatory cytokine release as well as activation of Th17 cells.
PRN694 demonstrates inhibitory activity against T-cell prolymphocytic leukemia cells in ex vivo assays.
PRN694 is a potent inhibitor of Th1 and Th17 differentiation and cytokine production, markedly reduces disease progression in models of colitis.
| M.Wt | 543.67 | |
| Formula | C28H35F2N5O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Zhong Y, et al. J Biol Chem. 2015 Mar 6;290(10):5960-78.
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