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PTC-124

Chemical Structure : PTC-124

CAS No.: 775304-57-9

PTC-124 (Ataluren)

Catalog No.: PC-21295Not For Human Use, Lab Use Only.

PTC-124 (Ataluren, PTC124) is an orally bioavailable small molecule that selectively induces ribosomal readthrough of premature but not normal termination codons.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PTC-124 (Ataluren, PTC124) is an orally bioavailable small molecule that selectively induces ribosomal readthrough of premature but not normal termination codons.
PTC-124 (Ataluren) promotes suppression of the human CFTR-G542X nonsense allele in cystic fibrosis (CF) mouse model.
PTC-124 (Ataluren) is a potent firefly luciferase (FLuc) inhibitor with IC50 of 7 nM.
PTC-124 (Ataluren) promotes ribosomal readthrough of premature stop codons in mRNA and offers therapeutic potential for multiple genetic diseases.

Physicochemical Properties

M.Wt 284.25
Formula C15H9FN2O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-(5-(2-Fluorophenyl)-1,2,4-oxadiazol-3-yl)benzoic acid

References

1. Auld DS, et al. Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3585-90.

2. Du M, et al. Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):2064-9.

3. Welch EM, et al. Nature. 2007 May 3;447(7140):87-91.

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