PX-866 | PI3K inhibitor | Probechem Biochemicals

Chemical Structure : PX-866

CAS No.: 502632-66-8

PX-866 (Sonolisib, PX866)

Catalog No.: PC-27224Not For Human Use, Lab Use Only.

Sonolisib (PX-866) is a Wortmannin analogue and an oral, irreversible, and pan-isoform PI3K inhibitor with IC50 of 0.1 nM, 1.0 nM and 2.9 nM for p110α, p120γ and p110δ.

Packing	Price	Stock
5 mg	$248	In stock
10 mg	$398	In stock
25 mg	$598	In stock
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Biological Activity

Sonolisib (PX-866) is a Wortmannin analogue and an oral, irreversible, and pan-isoform PI3K inhibitor with IC50 of 0.1 nM, 1.0 nM and 2.9 nM for p110α, p120γ and p110δ.
Sonolisib (PX-866) inhibits PI3-kinase signaling measured by phospho-Ser473-Akt levels in HT-29 colon cancer cells with IC50 of 20 nM.
Sonolisib (PX-866) at 10 mg/kg inhibited phospho-Ser473-Akt in HT-29 colon tumor xenografts up to 80% with recovery taking >48 hours after p.o. administration but more rapidly after i.v. or i.p. administration.
Sonolisib (PX-866) exhibited in vivo antitumor activity against s.c. OvCar-3 human ovarian cancer and A-549 human lung cancer xenografts in immunodeficient mice.

Physicochemical Properties

M.Wt	525.60
Formula	C29H35NO8
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Cyclopenta[5,6]naphtho[1,2-c]pyran-2,7,10(1H)-trione, 5-(acetyloxy)-1-[(di-2-propen-1-ylamino)methylene]-4,4a,5,6,6a,8,9,9a-octahydro-11-hydroxy-4-(methoxymethyl)-4a,6a-dimethyl-, (1E,4S,4aR,5R,6aS,9aR)-

References

1. Ihle NT, et al. Mol Cancer Ther. 2004 Jul;3(7):763-72.

2. Ihle NT, et al. Mol Cancer Ther. 2005 Sep;4(9):1349-57.

PX-866 (Sonolisib, PX866)

Biological Activity

Physicochemical Properties

References

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