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Chemical Structure : Pimodivir
CAS No.: 1629869-44-8
Catalog No.: PC-42998Not For Human Use, Lab Use Only.
Pimodivir (VX-787, JNJ872, JNJ 63623872) is a first-in-class, orally bioavailable inhibitor of influenza virus polymerase PB2 subunit with Kd of <3 nM, CPE EC50 of 2 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $188 | In stock | |
| 25 mg | $288 | In stock | |
| 50 mg | $458 | In stock | |
| 100 mg | Get quote | ||
| 200 mg | Get quote | ||
| 1 g | Get quote |
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Pimodivir (VX-787, JNJ872, JNJ 63623872) is a first-in-class, orally bioavailable inhibitor of influenza virus polymerase PB2 subunit with Kd of <3 nM, CPE EC50 of 2 nM.
Pimodivir (VX-787, JNJ872, JNJ 63623872) shows strong potency versus multiple influenza A strains, including pandemic 2009 H1N1 and avian H5N1 flu strains with mean CPE EC50 of <2 nM.
Pimodivir (VX-787) is highly efficacious in both prophylaxis and treatment models of mouse influenza and is superior to the neuraminidase inhibitor Oseltamivir.
| M.Wt | 399.394 | |
| Formula | C20H19F2N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 12.5 mg/mL |
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| Chemical Name/SMILES |
Bicyclo[2.2.2]octane-2-carboxylic acid, 3-[[5-fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-pyrimidinyl]amino]-, (2S,3S)- |
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1. Clark MP, et al. J Med Chem. 2014 Aug 14;57(15):6668-78.
2. Byrn RA, et al. Antimicrob Agents Chemother. 2015 Mar;59(3):1569-82.
3. Ma X, et al. Sci Rep. 2017 Aug 24;7(1):9385.
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