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Chemical Structure : QL-47
Catalog No.: PC-46006Not For Human Use, Lab Use Only.
QL-47 is a potent, selective, and irreversible BTK inhibitor with IC50 of 7 nM.
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QL-47 is a potent, selective, and irreversible BTK inhibitor with IC50 of 7 nM.
QL-47 inhibits BTK kinase activity with an IC50 of 7 nM, inhibits autophosphorylation of BTK on Tyr223 in cells with an EC50 of 475 nM, and inhibits phosphorylation of a downstream effector PLCγ2 (Tyr759) with an EC50 of 318 nM.
QL-47 induces a G1 cell cycle arrest that is associated with pronounced degradation of BTK protein in Ramos cells.
QL-47 inhibits the proliferation of B-cell lymphoma cancer cell lines at submicromolar concentrations.
| M.Wt | 447.4879 | |
| Formula | C27H21N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: < 9.4 mg/mL |
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1. Wu H, et al. ACS Chem Biol. 2014 May 16;9(5):1086-91.
2. Liang Y, et al. ACS Med Chem Lett. 2017 Feb 3;8(3):344-349.
3. Wang B, et al. Eur J Med Chem. 2017 Sep 8;137:545-557.
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