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QL-X-138

Chemical Structure : QL-X-138

CAS No.: 1469988-63-3

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QL-X-138

Catalog No.: PC-63076Not For Human Use, Lab Use Only.

QL-X-138 is a selective and potent BTK/MNK dual kinase inhibitor with IC50 of 8, 107.4, and 26 nM for BTK, MNK1, and MNK2, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    QL-X-138 is a selective and potent BTK/MNK dual kinase inhibitor with IC50 of 8, 107.4, and 26 nM for BTK, MNK1, and MNK2, respectively.
    QL-X-138 exhibits covalent binding to BTK and noncovalent binding to MNK.
    QL-X-138 enhances the antiproliferative efficacies in vitro against a variety of B-cell cancer cell lines, as well as AML and CLL primary patient cells.
    QL-X-138 arrests cell cycle progression and strongly induces apoptosis.

    Physicochemical Properties

    M.Wt 421.46
    Formula C25H19N5O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-[2-Methyl-5-[2-oxo-9-(1H-pyrazol-4-yl)benzo[h]-1,6-naphthyridin-1(2H)-yl]phenyl]-2-propenamide

    References

    1. Wu H, et al. Leukemia. 2016 Jan;30(1):173-81.

    2. Wang B, et al. Eur J Med Chem. 2017 Sep 8;137:545-557.

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