Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : QL-X-138
Catalog No.: PC-63076Not For Human Use, Lab Use Only.
QL-X-138 is a selective and potent BTK/MNK dual kinase inhibitor with IC50 of 8, 107.4, and 26 nM for BTK, MNK1, and MNK2, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | Get quote | ||
| 50 mg | Get quote | ||
| 100 mg | Get quote | ||
| 200 mg | Get quote | ||
| 1 g | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
QL-X-138 is a selective and potent BTK/MNK dual kinase inhibitor with IC50 of 8, 107.4, and 26 nM for BTK, MNK1, and MNK2, respectively.
QL-X-138 exhibits covalent binding to BTK and noncovalent binding to MNK.
QL-X-138 enhances the antiproliferative efficacies in vitro against a variety of B-cell cancer cell lines, as well as AML and CLL primary patient cells.
QL-X-138 arrests cell cycle progression and strongly induces apoptosis.
| M.Wt | 421.46 | |
| Formula | C25H19N5O2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Wu H, et al. Leukemia. 2016 Jan;30(1):173-81.
2. Wang B, et al. Eur J Med Chem. 2017 Sep 8;137:545-557.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
