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Chemical Structure : Quilseconazole
Catalog No.: PC-60051Not For Human Use, Lab Use Only.
A novel selective, orally available fungal CYP51 (lanosterol 14-α-demethylase) inhibitor.
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A novel selective, orally available fungal CYP51 (lanosterol 14-α-demethylase) inhibitor; displays greater selectivity for fungal enzyme than for mammalian CYP450 compared to the approved azole class of antifungal drugs; inhibits C. albicans and T. rubrum with MIC of <0.001 ug/mL, also demonstrated potent activities against Cryptococcusspecies as demonstrated by low MIC50 and MIC90 values.
| M.Wt | 513.376 | |
| Formula | C22H14F7N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Hoekstra WJ, et al. Bioorg Med Chem Lett. 2014 Aug 1;24(15):3455-8.
2. Lockhart SR, et al. Antimicrob Agents Chemother. 2016 Mar 25;60(4):2528-31.
3. Warrilow AG, et al. Antimicrob Agents Chemother. 2016 Jul 22;60(8):4530-8.
4. Nielsen K, et al. Med Mycol. 2017 Jun 1;55(4):453-456.
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