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Chemical Structure : REDX-05358
Catalog No.: PC-61974Not For Human Use, Lab Use Only.
REDX-05358 is a potent, highly selective, orally bioavailable pan RAF inhibitor with IC50 of 0.1, 0.68, 0.171, and 0.076 nM for ARAF, BRAF, BRAF (V600E), and CRAF, respectively.
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REDX-05358 is a potent, highly selective, orally bioavailable pan RAF inhibitor with IC50 of 0.1, 0.68, 0.171, and 0.076 nM for ARAF, BRAF, BRAF (V600E), and CRAF, respectively.
REDX-05358 demonstrates high selectivity profile against a panel of 468 kinases, exhibits negligible paradoxical activation due to inhibition of both RAF monomers and dimers.
REDX-05358 not only inhibits MAPK signalling in BRAF V600E mutant tumor cells, but also in those harbouring NRAS and KRAS mutations.
REDX-05358 exhibits in vivo efficacy in BRAF V600E CRC xenograft model.
| M.Wt | 472.929 | |
| Formula | C26H21ClN4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Helen Mason, et al. AACR, Abstract 5160.
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