Chemical Structure : RIPK1 inhibitor 62
CAS No.:
2764894-01-9
RIPK1 inhibitor 62
Catalog No.: PC-21707Not For Human Use, Lab Use Only.
RIPK1 inhibitor 62 is a potent, selective, orally bioavailable type-II kinase inhibitor of RIPK1 with IC50 of 3.5 nM (hRIPK1), 200-fold less potent against hRIPK3.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
RIPK1 inhibitor 62 is a potent, selective, orally bioavailable type-II kinase inhibitor of RIPK1 with IC50 of 3.5 nM (hRIPK1), 200-fold less potent against hRIPK3.
RIPK1 inhibitor 62 (8 nM) is able to abolish the stimulated phosphorylation and activation of RIPK1 and MLKL, and eliminates most phosphorylation of RIPK3 in FADD−/− Jurkat cells.
RIPK1 inhibitor 62 (2 mpk, p.o.) completely mitigated the acute hypothermia in mouse models of RIPK1-dependent acute or chronic inflammatory disease.
RIPK1 inhibitor 62 (15 or 30 mpk for 8 days, daily) could effectively eliminate most RA symptoms, including paw edema, erythema, and joint stiffness, without affecting the bodyweight in mice.
Physicochemical Properties
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M.Wt
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478.56
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Formula
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C27H26N8O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(S)-5-(1-(4-(6-Amino-9H-purin-9-yl)phenyl)ethyl)-3-benzyl-2-methyl-2,5,6,7-tetrahydro-4H-pyrazolo[4,3-c]pyridin-4-one
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References
1. Qin Y, et al. Acta Pharm Sin B. 2024 Jan;14(1):319-334.
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