Catalog No.: PC-36066Not For Human Use, Lab Use Only.
RIPK2 inhibitor OD36 is a potent, specific, ATP-competitive inhibitor of RIPK2 with IC50 of 5.3 nM, inhibits Tyr and Ser/Thr-directed activities of RIPK2.
RIPK2 inhibitor OD36 is a potent, specific, ATP-competitive inhibitor of RIPK2 with IC50 of 5.3 nM, inhibits Tyr and Ser/Thr-directed activities of RIPK2。
RIPK2 inhibitor OD36 inhibits both RIPK2 tyrosine autophosphorylation as well as downstream NF-κB and MAPK signaling induced by MDP, downregulates a panel of RIPK2 kinase-dependent genes。
RIPK2 inhibitor OD36 reduces cellular infiltration in an in vivo MDP-induced peritonitis model。
RIPK2 inhibitor OD36 also shows high affinity for cyclin G-associated kinase (GAK) with Ki of 3.8 nM.
