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Chemical Structure : RIPK2 inhibitor OD36
CAS No.: 1638644-62-8
Catalog No.: PC-36066Not For Human Use, Lab Use Only.
RIPK2 inhibitor OD36 is a potent, specific, ATP-competitive inhibitor of RIPK2 with IC50 of 5.3 nM, inhibits Tyr and Ser/Thr-directed activities of RIPK2.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg | $258 | In stock | |
| 5 mg | $498 | In stock | |
| 10 mg | $758 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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RIPK2 inhibitor OD36 is a potent, specific, ATP-competitive inhibitor of RIPK2 with IC50 of 5.3 nM, inhibits Tyr and Ser/Thr-directed activities of RIPK2。
RIPK2 inhibitor OD36 inhibits both RIPK2 tyrosine autophosphorylation as well as downstream NF-κB and MAPK signaling induced by MDP, downregulates a panel of RIPK2 kinase-dependent genes。
RIPK2 inhibitor OD36 reduces cellular infiltration in an in vivo MDP-induced peritonitis model。
RIPK2 inhibitor OD36 also shows high affinity for cyclin G-associated kinase (GAK) with Ki of 3.8 nM.
| M.Wt | 330.772 | |
| Formula | C16H15ClN4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(13Z,14E)-25-chloro-3,6-dioxa-9-aza-1(3,5)-pyrazolo[1,5-a]pyrimidina-2(1,3)-benzenacyclononaphane |
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1. Tigno-Aranjuez JT, et al. J Biol Chem. 2014 Oct 24;289(43):29651-64.
2. Asquith CRM, et al. J Med Chem. 2019 Feb 15. doi: 10.1021/acs.jmedchem.8b01213.
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