Catalog No.: PC-38731Not For Human Use, Lab Use Only.
RKI-1447 is a potent small molecule inhibitor of ROCK1 and ROCK2 with IC50 of 14.5 nM and 6.2 nM, respectively, suppresses phosphorylation of the ROCK substrates MLC-2 and MYPT-1 in human cancer cells.
RKI-1447 is a potent small molecule inhibitor of ROCK1 and ROCK2 with IC50 of 14.5 nM and 6.2 nM, respectively, suppresses phosphorylation of the ROCK substrates MLC-2 and MYPT-1 in human cancer cells.
RKI-1447 binds the ATP binding site through interactions with the hinge region and the DFG motif.
RKI-1447 shows no effect on the phosphorylation levels of the AKT, MEK, and S6 kinase.
RKI-1447 inhibited migration, invasion and anchorage-independent tumor growth of breast cancer cells (MDA-MB-231 cells, IC50=709 nM).
RKI-1447 is highly effective at inhibiting the outgrowth of mammary tumors in a transgenic mouse model.
