RO1138452 | IP receptor inhibitor | Probechem Biochemicals

Chemical Structure : RO1138452

CAS No.: 221529-58-4

RO1138452 (CAY10441, RO 1138452)

Catalog No.: PC-35353Not For Human Use, Lab Use Only.

RO1138452 is a potent, selective antagonist of prostacyclin receptor (IP receptor), inhibits carbaprostacylin-stimulated c-AMP accumulation in human SH-SY5Y neuroblastoma cells with pKb of 8.8.

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Biological Activity

RO1138452 is a potent, selective antagonist of prostacyclin receptor (IP receptor), inhibits carbaprostacylin-stimulated c-AMP accumulation in human SH-SY5Y neuroblastoma cells with pKb of 8.8.
RO1138452 does not display significant affinity for cloned human EP1, EP3, FP, and TP receptors.
RO1138452 suppresses Taprostene (1 uM)-induced inhibition of CXCL9 and CXCL10 release from BEAS-2B cells with pA50 (molar) values of -8.73 and -8.47.

Physicochemical Properties

M.Wt	309.413
Formula	C19H23N3O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(4,5-Dihydro-1H-imidazol-2-yl)-[4-(4-isopropoxy-benzyl)-phenyl]-amine

References

1. Bley KR, et al. Br J Pharmacol. 2006 Feb;147(3):335-45.

2. Jones RL, et al. Br J Pharmacol. 2006 Sep;149(1):110-20.

3. Ayer LM, et al. J Pharmacol Exp Ther. 2008 Feb;324(2):815-26.

4. Clark RD, et al. Bioorg Med Chem Lett. 2004 Feb 23;14(4):1053-6.

RO1138452 (CAY10441, RO 1138452)

Biological Activity

Physicochemical Properties

References

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