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Chemical Structure : RO1138452
Catalog No.: PC-35353Not For Human Use, Lab Use Only.
RO1138452 is a potent, selective antagonist of prostacyclin receptor (IP receptor), inhibits carbaprostacylin-stimulated c-AMP accumulation in human SH-SY5Y neuroblastoma cells with pKb of 8.8.
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RO1138452 is a potent, selective antagonist of prostacyclin receptor (IP receptor), inhibits carbaprostacylin-stimulated c-AMP accumulation in human SH-SY5Y neuroblastoma cells with pKb of 8.8; does not display significant affinity for cloned human EP1, EP3, FP, and TP receptors; suppresses Taprostene (1 uM)-induced inhibition of CXCL9 and CXCL10 release from BEAS-2B cells with pA50 (molar) values of -8.73 and -8.47.
| M.Wt | 309.413 | |
| Formula | C19H23N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Bley KR, et al. Br J Pharmacol. 2006 Feb;147(3):335-45.
2. Jones RL, et al. Br J Pharmacol. 2006 Sep;149(1):110-20.
3. Ayer LM, et al. J Pharmacol Exp Ther. 2008 Feb;324(2):815-26.
4. Clark RD, et al. Bioorg Med Chem Lett. 2004 Feb 23;14(4):1053-6.
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