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Chemical Structure : RO4929097
CAS No.: 847925-91-1
Catalog No.: PC-42810Not For Human Use, Lab Use Only.
RO4929097 (RG 4733) is a potent, selective, orally active γ-secretase inhibitor with IC50 of 4 nM, inhibits Notch processing in the Notch cell-based reporter assay with IC50 of 5 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $78 | In stock | |
| 10 mg | $118 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | Get quote |
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RO4929097 (RG 4733) is a potent, selective, orally active γ-secretase inhibitor with IC50 of 4 nM, inhibits Notch processing in the Notch cell-based reporter assay with IC50 of 5 nM.
RO4929097 (RG 4733) displays >100-fold selectivity against a panel of 75 other proteins of various types including receptors, ion channels and enzymes.
RO4929097 (RG 4733) inhibits Notch processing in human tumor-derived cells, inhibits the production of ICN, reducing the expression of the downstream Notch target Hes1 in A549 cells.
RO4929097 (RG 4733) demonstrates in vivo efficacy in A549 xenograft model.
| M.Wt | 469.4045 | |
| Formula | C22H20F5N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 49 mg/mL |
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| Chemical Name/SMILES |
Propanediamide, N1-[(7S)-6,7-dihydro-6-oxo-5H-dibenz[b,d]azepin-7-yl]-2,2-dimethyl-N3-(2,2,3,3,3-pentafluoropropyl)- |
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1. Debeb BG, et al. Breast Cancer Res Treat. 2012 Jul;134(2):495-510.
2. Kaur G, et al. Cancer Lett. 2016 Feb 28;371(2):225-39.
3. He W, et al. Mol Oncol. 2011 Jun;5(3):292-301.
4. Luistro L, et al. Cancer Res. 2009 Oct 1;69(19):7672-80.
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