Catalog No.: PC-42810Not For Human Use, Lab Use Only.
RO4929097 (RG 4733) is a potent, selective, orally active γ-secretase inhibitor with IC50 of 4 nM, inhibits Notch processing in the Notch cell-based reporter assay with IC50 of 5 nM.
RO4929097 (RG 4733) is a potent, selective, orally active γ-secretase inhibitor with IC50 of 4 nM, inhibits Notch processing in the Notch cell-based reporter assay with IC50 of 5 nM.
RO4929097 (RG 4733) displays >100-fold selectivity against a panel of 75 other proteins of various types including receptors, ion channels and enzymes.
RO4929097 (RG 4733) inhibits Notch processing in human tumor-derived cells, inhibits the production of ICN, reducing the expression of the downstream Notch target Hes1 in A549 cells.
RO4929097 (RG 4733) demonstrates in vivo efficacy in A549 xenograft model.
