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RWJ 67657

Chemical Structure : RWJ 67657

CAS No.: 215303-72-3

RWJ 67657 (JNJ 3026582, RWJ67657, RWJ-67657)

Catalog No.: PC-60627Not For Human Use, Lab Use Only.

RWJ 67657 (JNJ 3026582) is a potent, selective, orally active p38 MAPK inhibitor that inhibits the production of TNF-α and IL-1β by LPS-stimulated human PBMCs with IC50 of 3 and 11 nM, respectively.

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Biological Activity

RWJ 67657 (JNJ 3026582) is a potent, selective, orally active p38 MAPK inhibitor that inhibits the production of TNF-α and IL-1β by LPS-stimulated human PBMCs with IC50 of 3 and 11 nM, respectively.
RWJ 67657 inhibits p38α from purified LPS-activated human monocytes with IC50 of 30 nM, less potent for p38β.
RWJ 67657 also inhibits Src (IC50=5 uM), p65 Lck and no activity against other MAPKs and serine-threonine kinases.
RWJ 67657 inhibits TNF-alpha production in LPS-injected mice.

Physicochemical Properties

M.Wt 425.5
Formula C27H24FN3O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-[4-(4-fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol -2-yl]-3-butyn-1-ol

References

1. Wadsworth SA, et al. J Pharmacol Exp Ther. 1999 Nov;291(2):680-7.

2. Schafer PH, et al. J Immunol. 1999 Jun 15;162(12):7110-9.

3. Fijen JW, et al. Clin Exp Immunol. 2001 Apr;124(1):16-20.

4. Faas MM, et al. Clin Exp Immunol. 2002 Feb;127(2):337-43.

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