Catalog No.: PC-60627Not For Human Use, Lab Use Only.
RWJ 67657 (JNJ 3026582) is a potent, selective, orally active p38 MAPK inhibitor that inhibits the production of TNF-α and IL-1β by LPS-stimulated human PBMCs with IC50 of 3 and 11 nM, respectively.
RWJ 67657 (JNJ 3026582) is a potent, selective, orally active p38 MAPK inhibitor that inhibits the production of TNF-α and IL-1β by LPS-stimulated human PBMCs with IC50 of 3 and 11 nM, respectively.
RWJ 67657 inhibits p38α from purified LPS-activated human monocytes with IC50 of 30 nM, less potent for p38β.
RWJ 67657 also inhibits Src (IC50=5 uM), p65 Lck and no activity against other MAPKs and serine-threonine kinases.
RWJ 67657 inhibits TNF-alpha production in LPS-injected mice.
