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Chemical Structure : RWJ 67657
CAS No.: 215303-72-3
Catalog No.: PC-60627Not For Human Use, Lab Use Only.
RWJ 67657 is a potent, selective, orally active p38 MAPK inhibitor that inhibits the production of TNF-α and IL-1β by LPS-stimulated human PBMCs with IC50 of 3 and 11 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $248 | In stock | |
| 50 mg | $398 | In stock | |
| 100 mg | $688 | In stock | |
| 250 mg | Get quote | ||
| 1 g | Get quote |
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RWJ 67657 is a potent, selective, orally active p38 MAPK inhibitor that inhibits the production of TNF-α and IL-1β by LPS-stimulated human PBMCs with IC50 of 3 and 11 nM, respectively.
RWJ 67657 inhibits p38α from purified LPS-activated human monocytes with IC50 of 30 nM, less potent for p38β.
RWJ 67657 also inhibits Src (IC50=5 uM), p65 Lck and no activity against other MAPKs and serine-threonine kinases.
RWJ 67657 inhibits TNF-alpha production in LPS-injected mice.
| M.Wt | 425.5 | |
| Formula | C27H24FN3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-[4-(4-fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol -2-yl]-3-butyn-1-ol |
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1. Wadsworth SA, et al. J Pharmacol Exp Ther. 1999 Nov;291(2):680-7.
2. Schafer PH, et al. J Immunol. 1999 Jun 15;162(12):7110-9.
3. Fijen JW, et al. Clin Exp Immunol. 2001 Apr;124(1):16-20.
4. Faas MM, et al. Clin Exp Immunol. 2002 Feb;127(2):337-43.
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