Chemical Structure : Radotinib
CAS No.:
926037-48-1
Radotinib
(IY5511, IY-5511)
Catalog No. : PC-38025Not For Human Use, Lab Use Only.
Radotinib (IY-5511) is a potent and selective BCR-ABL1 tyrosine kinase inhibitor with IC50 of 34 nM for wild-type BCR-ABL1 kinase.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-3802501
Biological Activity
Radotinib (IY-5511) is a potent and selective BCR-ABL1 tyrosine kinase inhibitor with IC50 of 34 nM for wild-type BCR-ABL1 kinase.
Physicochemical Properties
M.Wt
530.5
Formula
C27H21F3N8O
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-(pyrazin-2-yl)pyrimidin-2-yl)amino)benzamide
References
1. Kim SH, et al. Haematologica.
2. Heo SK, et al. PLoS One.
3. Kwak JY, et al. Clin Cancer Res.
4. Heo SK, et al. Sci Rep.
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