Catalog No.: PC-23081Not For Human Use, Lab Use Only.
Rocbrutinib (LP-168) is a potent, highly selective, orally available next-generation inhibitor of Bruton's tyrosine kinase (BTK) inhibitor with IC50 of 0.11 nM against wild-type BTK and IC50 of 1.0 nM against C481S-mutated BTK.
Rocbrutinib (LP-168) is a potent, highly selective, orally available next-generation inhibitor of Bruton's tyrosine kinase (BTK) inhibitor with IC50 of 0.11 nM against wild-type BTK and IC50 of 1.0 nM against C481S-mutated BTK.
Rocbrutinib (LP-168) can bind wild-type BTK covalently and C481-mutated BTK non-covalently (reversibly).
Rocbrutinib (LP-168) reduces the viability of leukemia cells, induces cytotoxicity and inhibits cell migration, shows preclinical activity in resistant CLL models.
