Catalog No.: PC-43299Not For Human Use, Lab Use Only.
S49076 is a potent, ATP-competitive tyrosine kinase inhibitor of MET, AXL/MER, and FGFR1/2/3 with IC50 of <20 nM, also potently inhibits the kinase activity of mutated isoforms of MET (D1246N, Y1248D, Y1248H) and FGFR1/2.
S49076 is a potent, ATP-competitive tyrosine kinase inhibitor of MET,AXL/MER, and FGFR1/2/3 with IC50 of <20 nM, also potently inhibits the kinase activity of mutated isoforms of MET (D1246N, Y1248D, Y1248H) and FGFR1/2.
S49076 only inhibits 6% of kinases on a panel of 442 human wild-type and mutated kiTAM/FGFTnases at 100 nM.
S49076 inhibits the proliferation of MET- and FGFR2-dependent gastric cancer cells, blocks MET-driven migration of lung carcinoma cells, and inhibits colony formation of hepatocarcinoma cells expressing FGFR1/2 and AXL.
S49076 causes tumor growth arrest in bevacizumab-resistant tumors in cancer xenograft models.
