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Chemical Structure : S49076
CAS No.: 1265965-22-7
Catalog No.: PC-43299Not For Human Use, Lab Use Only.
S49076 is a potent, ATP-competitive tyrosine kinase inhibitor of MET, AXL/MER, and FGFR1/2/3 with IC50 of <20 nM, also potently inhibits the kinase activity of mutated isoforms of MET (D1246N, Y1248D, Y1248H) and FGFR1/2.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg (Free Sample) | $18 | In stock | |
| 5 mg | $88 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | Get quote | ||
| 50 mg | Get quote |
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S49076 is a potent, ATP-competitive tyrosine kinase inhibitor of MET, AXL/MER, and FGFR1/2/3 with IC50 of <20 nM, also potently inhibits the kinase activity of mutated isoforms of MET (D1246N, Y1248D, Y1248H) and FGFR1/2.
S49076 only inhibits 6% of kinases on a panel of 442 human wild-type and mutated kinases at 100 nM.
S49076 inhibits the proliferation of MET- and FGFR2-dependent gastric cancer cells, blocks MET-driven migration of lung carcinoma cells, and inhibits colony formation of hepatocarcinoma cells expressing FGFR1/2 and AXL.
S49076 causes tumor growth arrest in bevacizumab-resistant tumors in cancer xenograft models.
| M.Wt | 438.4995 | |
| Formula | C22H22N4O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 31 mg/mL |
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| Chemical Name/SMILES |
2,4-Thiazolidinedione, 3-[[2,3-dihydro-3-[[4-(4-morpholinylmethyl)-1H-pyrrol-2-yl]methylene]-2-oxo-1H-indol-5-yl]methyl]- |
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1. Burbridge MF, et al. Mol Cancer Ther. 2013 Sep;12(9):1749-62.
2. Clémenson C, et al. Mol Cancer Ther. 2017 Oct;16(10):2107-2119.
3. Rodon J, et al. Eur J Cancer. 2017 Aug;81:142-150.
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