Catalog No.: PC-20110Not For Human Use, Lab Use Only.
SCH-442416 (SCH442416) is a potent, selective and brain-penetrant antagonist of adenosine A2A receptor (A2AR) with Ki 0.048 nM and 0.5 nM for human and rat A2AR, respectively.
SCH-442416 (SCH442416) is a potent, selective and brain-penetrant antagonist of adenosine A2A receptor (A2AR) with Ki 0.048 nM and 0.5 nM for human and rat A2AR, respectively.
SCH-442416 displays >23000-fold selectivity over A1R, A2BR, and A3R (Ki=1111, 10000, and 10000 nM, respectively).
SCH 442416 (10 μM) attenuates adenosine-mediated and A2AR agonist-induced arteriole dilation.
SCH-442416 (0.017 mg/kg; i.p.) completely abrogates the CGS-21680-induced decrease in skeletal muscle injury.
