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Chemical Structure : SCH-442416
CAS No.: 316173-57-6
Catalog No.: PC-20110Not For Human Use, Lab Use Only.
SCH-442416 (SCH442416) is a potent, selective and brain-penetrant antagonist of adenosine A2A receptor (A2AR) with Ki 0.048 nM and 0.5 nM for human and rat A2AR, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $358 | In stock | |
| 100 mg | Get quote |
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SCH-442416 (SCH442416) is a potent, selective and brain-penetrant antagonist of adenosine A2A receptor (A2AR) with Ki 0.048 nM and 0.5 nM for human and rat A2AR, respectively.
SCH-442416 displays >23000-fold selectivity over A1R, A2BR, and A3R (Ki=1111, 10000, and 10000 nM, respectively).
SCH 442416 (10 μM) attenuates adenosine-mediated and A2AR agonist-induced arteriole dilation.
SCH-442416 (0.017 mg/kg; i.p.) completely abrogates the CGS-21680-induced decrease in skeletal muscle injury.
| M.Wt | 389.42 | |
| Formula | C20H19N7O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-(2-Furanyl)-7-[3-(4-methoxyphenyl)propyl]-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine |
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1. Todde S, et al. J Med Chem. 2000 Nov 16;43(23):4359-62.
2. Rahimian R, et al. Eur J Pharmacol. 2010 Dec 15;649(1-3):376-81.
3. Kumar TS, et al. Bioorg Med Chem Lett. 2011 May 1;21(9):2740-5.
4. Orrú M, et al. Neuropharmacology. 2011 Oct-Nov;61(5-6):967-74.
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