SD0006 | p38α inhibitor | Probechem Biochemicals

Chemical Structure : SD0006

CAS No.: 271576-80-8

SD0006 (SD06, SD-0006)

Catalog No.: PC-42805Not For Human Use, Lab Use Only.

SD0006 (SD-0006, SD-06) is a potent, selective, ATP-competitive and orally bioavailable p38α inhibitor with Ki of 61 nM.

Packing	Price	Stock
1 mg (Free Sample)	$28	In stock
5 mg	$78	In stock
10 mg	$128	In stock
25 mg	$218	In stock
50 mg	$358	In stock
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Biological Activity

SD0006 (SD-0006, SD-06) is a potent, selective, ATP-competitive and orally bioavailable p38α inhibitor with Ki of 61 nM.

SD0006 displays 8-fold selectivity over p38β (Ki=510 nM), and greater than 100-fold selectivity based upon IC50 ratios over the other MAPKs p38γ, p38δ, ERK-2 and JNK-1, -2, and -3.

SD0006 potently inhibits tumor necrosis factor-alpha (TNFalpha) release, in vitro and in vivo, with IC50 of <200 nM.

SD0006 is effective in the rat streptococcal-cell-wall-induced arthritis model, with dramatic protective effects on paw joint integrity and bone density as shown by radiographic analysis.

SD0006 also demonstrates good oral anti-inflammatory efficacy with excellent cross-species correlation between the rat, cynomolgus monkey, and human.

Physicochemical Properties

M.Wt	397.8581
Formula	C20H20ClN5O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	DMSO: ≥ 29 mg/mL
Chemical Name/SMILES	Ethanone, 1-[4-[5-(4-chlorophenyl)-4-(4-pyrimidinyl)-1H-pyrazol-3-yl]-1-piperidinyl]-2-hydroxy-

References

1. Burnette BL, et al. Pharmacology. 2009;84(1):42-60.
2. Walker JK, et al. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2634-8.

SD0006 (SD06, SD-0006)

Biological Activity

Physicochemical Properties

References

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