SDUY104 | SHP2 inhibitor | Probechem Biochemicals

Chemical Structure : SDUY104

SDUY104 (SDUY-104)

Catalog No.: PC-27019Not For Human Use, Lab Use Only.

SDUY104 is a potent, selective, allosteric SHP2 inhibitor with enzymatic IC50 of 0.14 uM.

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Biological Activity

SDUY104 is a potent, selective, allosteric SHP2 inhibitor with enzymatic IC50 of 0.14 uM.
SDUY104 significantly impaired the proliferation of KRAS-driven pancreatic cancer cells by inducing cell-cycle arrest and apoptosis.
SDUY104 suppressed MAPK signaling while triggering compensatory PI3K-AKT activation.
Combining SDUY104 with ERK inhibitor Ulixertinib produced synergistic antiproliferative activity via enhanced MAPK suppression. Combination of SDUY104 with PI3K inhibitor BKM-120 exhibited superior antitumor activity compared to either monotherapy in PANC-1 xenograft model.

Physicochemical Properties

M.Wt	453.99
Formula	C24H24ClN3O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-(1-amino-1,3-dihydrospiro[indene-2,4'-piperidin]-1'-yl)(5-((3-amino-2-chlorophenyl)thio)furan-2-yl)methanone

References

1. Zhu C, et al. J Med Chem. 2026 Jun 9. doi: 10.1021/acs.jmedchem.6c00836.

SDUY104 (SDUY-104)

Biological Activity

Physicochemical Properties

References

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