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SF-1126

Chemical Structure : SF-1126

CAS No.: 936487-67-1

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SF-1126 (SF 1126;SF1126)

Catalog No.: PC-60413Not For Human Use, Lab Use Only.

SF-1126 is a pan PI3K/BRD4 inhibitor, RGDS-conjugated LY294002 prodrug that exhibits increased solubility and binds to specific integrins.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SF-1126 is a pan PI3K/BRD4 inhibitor, RGDS-conjugated LY294002 prodrug that exhibits increased solubility and binds to specific integrins; blocks expression levels of c-Myc in HCC cells, inhibits proliferation, cell cycle, apoptosis, PI3K/AKT/mTOR and Ras/Raf/MAPK pathway; shows significant antitumor activity in vivo.

    Liver Cancer

    Phase 1 Clinical

    Physicochemical Properties

    M.Wt 852.84
    Formula C39H48N8O14
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (4-oxo-4-((4-(4-oxo-8-phenyl-4H-chromen-2-yl)morpholino-4-ium)methoxy)butanoyl)-L-arginylglycyl-L-aspartyl-L-serinate

    References

    1. Garlich JR, et al. Cancer Res. 2008 Jan 1;68(1):206-15.

    2. Dittmann A, et al. ACS Chem Biol. 2014 Feb 21;9(2):495-502.

    3. Erdreich-Epstein A, et al. Oncotarget. 2016 Nov 16. doi: 10.18632/oncotarget.13386.

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