SGC-CAMKK2-1

Chemical Structure : SGC-CAMKK2-1

Catalog No.: PC-49623Not For Human Use, Lab Use Only.

SGC-CAMKK2-1 is a potent, selective chemical probe inhibitor that targets CaMKK2 with enzyme IC50 of 30 nM.

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Biological Activity

SGC-CAMKK2-1 is a potent, selective chemical probe inhibitor that targets CaMKK2 with enzyme IC50 of 30 nM.
SGC-CAMKK2-1 displays excellent broad kinome selectivity against a panel of more than 400 wild-type human kinases (S10 (1 µM)=0.002).
SGC-CAMKK2-1 binds directly to the CAMKK2 kinase domain (KD) (amino acids 161-449).
SGC-CAMKK2-1 has an IC50 of 270 nM in-cell target engagement assays, can engage CAMKK2 in cells at concentrations below 1 µM.
SGC-CAMKK2-1 decreased p-AMPK(Thr172) levels in C4-2 prostate cancer cells with IC50 of 1.6 uM, which is 7-fold more potent than STO-609 (Cat#PC-45723).

Physicochemical Properties

M.Wt	397.47
Formula	C26H23NO3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-cyclopentyl-4-(5-(m-tolyl)furo[2,3-b]pyridin-3-yl)benzoic acid

References

1. Carrow Wells, et al. Cells. 2023 Jan 11;12(2):287.

SGC-CAMKK2-1

Biological Activity

Physicochemical Properties

References

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