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Chemical Structure : SGC-CAMKK2-1
Catalog No.: PC-49623Not For Human Use, Lab Use Only.
SGC-CAMKK2-1 is a potent, selective chemical probe inhibitor that targets CAMKK2 with enzyme IC50 of 30 nM.
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SGC-CAMKK2-1 is a potent, selective chemical probe inhibitor that targets CAMKK2 with enzyme IC50 of 30 nM.
SGC-CAMKK2-1 displays excellent broad kinome selectivity against a panel of more than 400 wild-type human kinases (S10 (1 µM)=0.002).
SGC-CAMKK2-1 binds directly to the CAMKK2 kinase domain (KD) (amino acids 161-449).
SGC-CAMKK2-1 has an IC50 of 270 nM in-cell target engagement assays, can engage CAMKK2 in cells at concentrations below 1 µM.
SGC-CAMKK2-1 decreased p-AMPK(Thr172) levels in C4-2 prostate cancer cells with IC50 of 1.6 uM, which is 7-fold more potent than STO-609 (Cat#PC-45723).
| M.Wt | 397.47 | |
| Formula | C26H23NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Carrow Wells, et al. Cells. 2023 Jan 11;12(2):287.
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