Catalog No.: PC-43298Not For Human Use, Lab Use Only.
SGI-7079 is a potent, selective Axl inhibitor with Ki of 5.7 nM, inhibits Gas6 ligand-induced tyrosine phosphorylation of human AXL expressed in HEK293T cells with EC50 of 100 nM.
SGI-7079 is a potent, selective Axl inhibitor with Ki of 5.7 nM, inhibits Gas6 ligand-induced tyrosine phosphorylation of human AXL expressed in HEK293T cells with EC50 of 100 nM.
SGI-7079 inhibits proliferation of inflammatory breast cancer cells SUM149 and KPL-4 with IC50 of 0.43 and 0.15 uM.
SGI-7079 inhibits TAM family members MER and Tyro3, also shows potent, low nM inhibition of Syk, Flt1, Flt3, Jak2, TrkA, TrkB, PDGFRβ and Ret kinases.
SGI-7079 decreases invasion, halts the cell cycle in the G1 phase, and synergistically increases the potency of erlotinib.
SGI-7079 inhibits tumor growth mouse xenograft model of NSCLC, reverses erlotinib resistance combined with erlotinib.
