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Chemical Structure : SGI-7079
CAS No.: 1239875-86-5
Catalog No.: PC-43298Not For Human Use, Lab Use Only.
SGI-7079 is a potent, selective Axl inhibitor with Ki of 5.7 nM, inhibits Gas6 ligand-induced tyrosine phosphorylation of human AXL expressed in HEK293T cells with EC50 of 100 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg (Free Sample) | $18 | In stock | |
| 5 mg | $88 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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SGI-7079 is a potent, selective Axl inhibitor with Ki of 5.7 nM, inhibits Gas6 ligand-induced tyrosine phosphorylation of human AXL expressed in HEK293T cells with EC50 of 100 nM.
SGI-7079 inhibits proliferation of inflammatory breast cancer cells SUM149 and KPL-4 with IC50 of 0.43 and 0.15 uM.
SGI-7079 inhibits TAM family members MER and Tyro3, also shows potent, low nM inhibition of Syk, Flt1, Flt3, Jak2, TrkA, TrkB, PDGFRβ and Ret kinases.
SGI-7079 decreases invasion, halts the cell cycle in the G1 phase, and synergistically increases the potency of erlotinib.
SGI-7079 inhibits tumor growth mouse xenograft model of NSCLC, reverses erlotinib resistance combined with erlotinib.
| M.Wt | 455.5299 | |
| Formula | C26H26FN7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 34 mg/mL |
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| Chemical Name/SMILES |
Benzeneacetonitrile, 3-[2-[[3-fluoro-4-(4-methyl-1-piperazinyl)phenyl]amino]-5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl]- |
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1. Byers LA, et al. Clin Cancer Res. 2013 Jan 1;19(1):279-90.
2. Myers SH, et al. J Med Chem. 2016 Apr 28;59(8):3593-608.
3. Wang X, et al. Cancer Res. 2013 Nov 1;73(21):6516-25.
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