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SGL5213

Chemical Structure : SGL5213

CAS No.: 1240305-17-2

SGL5213 (SGL 5213)

Catalog No.: PC-49671Not For Human Use, Lab Use Only.

SGL5213 (SGL 5213) is potent, intestinal sodium-dependent glucose cotransporter (SGLT) inhibitor with IC50 of 29 and 20 nM for hSGLT1 and hSDGLT2, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SGL5213 (SGL 5213) is potent, intestinal sodium-dependent glucose cotransporter (SGLT) inhibitor with IC50 of 29 and 20 nM for hSGLT1 and hSDGLT2, respectively.
    SGL5213 had a glucose-lowering effect at 0.3 mg/kg (p.o.) in SD rats.
    Orally administered SGL5213 was hardly absorbed and its distribution was restricted to the gastrointestinal lumen.
    SGL5213 significantly improved post-prandial hyperglycemia in streptozotocin (STZ)-induced diabetic rats at doses of 1 mg/kg or more.
    SGL5213 suppressed intestinal glucose absorption and enhances plasma GLP-1 and GLP-2 secretion in rats.

    Physicochemical Properties

    M.Wt 669.85
    Formula C37H55N3O8
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (3E)-N-[2-[[2-(Dimethylamino)ethyl]amino]-1,1-dimethyl-2-oxoethyl]-4-[4-[[5-β-D-glucopyranosyl-4-methoxy-2-(1-methylethyl)phenyl]methyl]phenyl]-2,2-dimethyl-3-butenamide

    References

    1. Kuroda S, et al. Bioorg Med Chem. 2019 Jan 15;27(2):394-409.

    2. Io F, et al. Eur J Pharmacol. 2019 Jun 15;853:136-144.

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