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Chemical Structure : SGX-523
CAS No.: 1022150-57-7
Catalog No.: PC-42835Not For Human Use, Lab Use Only.
SGX-523 (SGX523) is a potent, selective ATP-competitive inhibitor of MET receptor tyrosine kinase with IC50 of 4 nM, does not inhibit RON and a panel of kinases.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg (Free Sample) | $18 | In stock | |
| 10 mg | $88 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $238 | In stock | |
| 100 mg | Get quote |
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SGX-523 (SGX523) is a potent, selective ATP-competitive inhibitor of MET receptor tyrosine kinase with IC50 of 4 nM, does not inhibit RON and a panel of kinases.
SGX-523 shows higher affinity for unphosphorylated form of MET (Ki = 2.7 nM) versus the more active phospho-MET (Ki=23 nM).
SGX-523 inhibits MET-mediated signaling, cell proliferation, and cell migration at nanomolar concentrations but has no effect on signaling dependent on other protein kinases.
SGX-523 inhibits MET autophosphorylation with IC50 of 40 nM in GTL16 cells, inhibits MET-dependent tumor growth in vivo.
| M.Wt | 359.4077 | |
| Formula | C18H13N7S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 3.6 mg/mL |
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| Chemical Name/SMILES |
Quinoline, 6-[[6-(1-methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]thio]- |
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1. Buchanan SG, et al. Mol Cancer Ther. 2009 Dec;8(12):3181-90.
2. Guessous F, et al. Anticancer Agents Med Chem. 2010 Jan;10(1):28-35.
3. Zhang YW, et al. Cancer Res. 2010 Sep 1;70(17):6880-90.
4. Xie Q, et al. Proc Natl Acad Sci U S A. 2012 Jan 10;109(2):570-5.
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