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Chemical Structure : SH-4-54
CAS No.: 1456632-40-8
Catalog No.: PC-45109Not For Human Use, Lab Use Only.
SH-4-54 is a potent, BBB permeable, nonphosphorylated STAT3 inhibitor that strongly binds to STAT3 protein with Kd of 300 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $158 | In stock | |
| 25 mg | $278 | In stock | |
| 50 mg | $458 | In stock | |
| 100 mg | Get quote |
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SH-4-54 is a potent, BBB permeable, nonphosphorylated STAT3 inhibitor that strongly binds to STAT3 protein with Kd of 300 nM.
SH-4-54 potently kills glioblastoma brain cancer stem cells (BTSCs) and effectively suppresses STAT3 phosphorylation and its downstream transcriptional targets at low nM concentrations.
SH-4-54 potently suppresses glioma tumor growth, and inhibits pSTAT3 in vivo.
| M.Wt | 610.5921 | |
| Formula | C29H27F5N2O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
Benzoic acid, 4-[[(4-cyclohexylphenyl)methyl][2-[methyl[(2,3,4,5,6-pentafluorophenyl)sulfonyl]amino]acetyl]amino]- |
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1. Haftchenary S, et al. ACS Med Chem Lett. 2013 Sep 8;4(11):1102-7.
2. Arpin CC, et al. Mol Cancer Ther. 2016 May;15(5):794-805.
3. Linher-Melville K, et al. PLoS One. 2016 Aug 11;11(8):e0161202.
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