SJG-136 | DNA cross-linking agent | Probechem Biochemicals

Chemical Structure : SJG-136

CAS No.: 232931-57-6

SJG-136 (SG2000, SJG136, NSC 694501)

Catalog No.: PC-22218Not For Human Use, Lab Use Only.

SJG-136 (SG2000, NSC 694501) is a potent DNA cross-linking agent and DNA-binding payload with XL50 (50% cross-linking of pBR322 DNA) of 45 nM, shows potent antitumor activity.

Packing	Price	Stock
1 mg	$258	In stock
5 mg	$458	In stock
10 mg	$698	In stock
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Biological Activity

SJG-136 (SG2000, NSC 694501) is a potent DNA cross-linking agent and DNA-binding payload with XL50 (50% cross-linking of pBR322 DNA) of 45 nM, shows potent antitumor activity.
SJG-136 is cytotoxic to ovarian cell lines, such as A2780 (IC50, 22.5 pM), A2780cisR (IC50, 24 pM), CH1 (IC50, 0.12 nM), CH1cisR (IC50, 0.6 nM), and SKOV-3 (IC50, 9.1 nM).
SJG-136 reduces the viability of a panel of canine cancer cells, with GI50 values ranging from 0.33 - >100 nM.
SJG-136 shows potent antitumor effect against CMeC-1 tumour at 0.30 mg/kg than 0.15 mg/kg in mice, induces H2AX phosphorylation.

Physicochemical Properties

M.Wt	556.62
Formula	C31H32N4O6
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(11aS,11a'S)-8,8'-(propane-1,3-diylbis(oxy))bis(7-methoxy-2-methylene-1,2,3,11a-tetrahydro-5H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-5-one)

References

1. Gregson SJ, et al. J Med Chem. 2001 Mar 1;44(5):737-48.

SJG-136 (SG2000, SJG136, NSC 694501)

Biological Activity

Physicochemical Properties

References

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