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Chemical Structure : SJG-136
CAS No.: 232931-57-6
Catalog No.: PC-22218Not For Human Use, Lab Use Only.
SJG-136 (SG2000, NSC 694501) is a potent DNA cross-linking agent and DNA-binding payload with XL50 (50% cross-linking of pBR322 DNA) of 45 nM, shows potent antitumor activity.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 1 mg | $258 | In stock | |
| 5 mg | $458 | In stock | |
| 10 mg | $698 | In stock | |
| 25 mg | Get quote | ||
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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SJG-136 (SG2000, NSC 694501) is a potent DNA cross-linking agent and DNA-binding payload with XL50 (50% cross-linking of pBR322 DNA) of 45 nM, shows potent antitumor activity.
SJG-136 is cytotoxic to ovarian cell lines, such as A2780 (IC50, 22.5 pM), A2780cisR (IC50, 24 pM), CH1 (IC50, 0.12 nM), CH1cisR (IC50, 0.6 nM), and SKOV-3 (IC50, 9.1 nM).
SJG-136 reduces the viability of a panel of canine cancer cells, with GI50 values ranging from 0.33 - >100 nM.
SJG-136 shows potent antitumor effect against CMeC-1 tumour at 0.30 mg/kg than 0.15 mg/kg in mice, induces H2AX phosphorylation.
| M.Wt | 556.62 | |
| Formula | C31H32N4O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(11aS,11a'S)-8,8'-(propane-1,3-diylbis(oxy))bis(7-methoxy-2-methylene-1,2,3,11a-tetrahydro-5H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-5-one) |
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1. Gregson SJ, et al. J Med Chem. 2001 Mar 1;44(5):737-48.
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