Chemical Structure : SLC-391
CAS No.:
1783825-18-2
SLC-391
(SLC391, SLC-0211)
Catalog No.: PC-24679Not For Human Use, Lab Use Only.
SLC-391 (SLC-0211) is a potent, selective small molecule inhibitor for AXL with IC50 of 9.6 nM, 4-fold selective over TYRO3 (IC=42.3 nM) and MER (IC50=44 nM).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
SLC-391 (SLC-0211) is a potent, selective small molecule inhibitor for AXL with IC50 of 9.6 nM, 4-fold selective over TYRO3 (IC=42.3 nM) and MER (IC50=44 nM).
SLC-391 demonstrates high selectivity against a panel of 93 individually expressed receptor tyrosine kinases using BaF3 cells.
SLC-391 stabilizes the AXL kinase domain, binds to its active site, and inhibits the growth of AML cells in vitro.
Dual SLC-391 and venetoclax treatment in vivo decreases leukemia burden and enhances survival of mice in 2 aggressive AML models.
Combination treatment with SLC-391 and venetoclax synergistically inhibits proliferation and long-term clonogenic activities of cells from patients with AML in vitro.
Combined treatment with SLC-391 and venetoclax decreases leukemia burden and significantly enhances survival of leukemic mice in a PDX model.
Physicochemical Properties
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M.Wt
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365.44
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Formula
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C19H23N7O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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3-(5-(cyclopropylmethyl)-1,3,4-oxadiazole-2-yl)-5-(1-(piperidine-4-yl)-1H-pyrazole-4-yl)pyridine-2-amine
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References
1. Xiaojia Niu, et al. Blood. 2021 Jul 1;137(26):3641-3655.
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