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Chemical Structure : SNDX5613
CAS No.: 2169919-21-3
Catalog No.: PC-72793Not For Human Use, Lab Use Only.
Revumenib (SNDX-5613) is a potent and selective inhibitor of menin-MLL binding with Ki of 0.149 nM.
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|---|---|---|---|
| 5 mg | $148 | In stock | |
| 10 mg | $248 | In stock | |
| 25 mg | $428 | In stock | |
| 50 mg | $728 | In stock | |
| 100 mg | Get quote |
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Revumenib (SNDX-5613) is a potent and selective inhibitor of menin-MLL binding with Ki of 0.149 nM.
SNDX5613 shows anti-proliferative activity against multiple cell lines harboring MLLr translocations (MV4;11, RS4;11, MOLM-13, KOPN-8) with IC50 values ranging from 10-20 nM.
Treatment with SNDX-5613 and venetoclax reduced leukemia burden and significantly improved survival of NSG mice bearing MLL1-r or mtNPM1 with mtFLT3 AML xenografts.
| M.Wt | 630.82 | |
| Formula | C32H47FN6O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-ethyl-2-((4-(7-(((1r,4r)-4-(ethylsulfonamido)cyclohexyl)methyl)-2,7-diazaspiro[3.5]nonan-2-yl)pyrimidin-5-yl)oxy)-5-fluoro-N-isopropylbenzamide |
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1. Warren Fiskus, et al. Blood Cancer J. 2022 Jan 11;12(1):5.
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