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Chemical Structure : SPD-304
CAS No.: 869998-49-2
Catalog No.: PC-61313Not For Human Use, Lab Use Only.
SPD-304 is an inhibitor of tumor necrosis factor α (TNFα) that prevents binding to the TNF Receptor 1 (TNFR1) with IC50 of 22 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $298 | In stock | |
| 10 mg | $458 | In stock | |
| 25 mg | $758 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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SPD-304 (TNFα inhibitor X) is an inhibitor of tumor necrosis factor α (TNFα) that prevents binding to the TNF Receptor 1 (TNFR1) with IC50 of 22 uM.
SPD-304 (TNFα inhibitor X) binds to the biologically active TNFα trimer and promotes accelerated displacement of a single subunit to rapidly inactivate the cytokine.
SPD-304 (TNFα inhibitor X) inhibits TNFα-mediated stimulation of IKB degradation with an IC50 of 4.6 uM in a cell based assay.
| M.Wt | 547.622 | |
| Formula | C32H32F3N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
6,7-dimethyl-3-((methyl(2-(methyl((1-(3-(trifluoromethyl)phenyl)-1H-indol-3-yl)methyl)amino)ethyl)amino)methyl)-4H-chromen-4-one |
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1. He MM, et al. Science. 2005 Nov 11;310(5750):1022-5.
2. Chang YJ, et al. PLoS One. 2015 Mar 27;10(3):e0120713.
3. Blevitt JM, et al. J Med Chem. 2017 Apr 27;60(8):3511-3517.
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