Chemical Structure : SQ-29548
CAS No.:
98672-91-4
SQ-29548
(SQ29548, SQ-29,548)
Catalog No.: PC-20722Not For Human Use, Lab Use Only.
SQ-29548 (SQ-29,548) is a potent and specific antagonist of thromboxane-prostanoid (TP) receptor with binding Ki value of 4.1 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
SQ-29548 (SQ-29,548) is a potent and specific antagonist of thromboxane-prostanoid (TP) receptor with binding Ki value of 4.1 nM.
SQ-29548 inhibits platelet aggregation induced by AA, the endoperoxide analog U-46,619 or collagen in platelet-rich plasma with IC50 of 0.8, 0.3 or 2.9 microM, respectively.
SQ-29548 does not affect ADP and platelet-activating factor acether-induced platelet aggregation, and thromboxane B2 formation.
SQ-29548 antagonizes U-46619 induced contraction of rat and guinea pig tracheal, arterial, and venous smooth muscles with drug/receptor dissociation constants (KB) in the range of 0.5-1.7 nM.
Physicochemical Properties
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M.Wt
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387.48
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Formula
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C21H29N3O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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O=C(O)CCC/C=C\CC1C(O2)CCC2C1CNNC(NC3=CC=CC=C3)=O
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References
1. H Darius, et al. J Pharmacol Exp Ther. 1985 Nov;235(2):274-81.
2. Ogletree ML, et al. J Pharmacol Exp Ther. 1992.
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