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Chemical Structure : SSI-4
CAS No.: 1875084-68-6
Catalog No.: PC-23303Not For Human Use, Lab Use Only.
SSI-4 is a highly potent, selective inhibitor of lipogenic enzyme stearoyl-CoA desaturase 1 (SCD1) with IC50 of 1.9 nM in in vitro enzymatic inhibition assays.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $388 | In stock | |
| 10 mg | $558 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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SSI-4 is a highly potent, selective inhibitor of lipogenic enzyme stearoyl-CoA desaturase 1 (SCD1) with IC50 of 1.9 nM in in vitro enzymatic inhibition assays.
SSI-4 displays excellent selectivity against 468 known kinases, with only 1 kinase (CDKL2) at concentration of 100 nM for binding.
SSI-4 impaired tumor cell proliferation in 15/19 different tumor cell lines representing a broad spectrum of cancers, while normal cells remained unaffected.
Oral administration of SSI-4 resulted in growth inhibition of A498 ccRCC tumors, also reduced pulmonary metastasis formation of ACHN ccRCC.
| M.Wt | 388.85 | |
| Formula | C19H21ClN4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-Pyridinecarboxamide, 2-[[[4-(2-chlorophenoxy)-1-piperidinyl]carbonyl]amino]-N-methyl- |
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1. Dembitz V, et al. Leukemia. 2024 Aug 26. doi: 10.1038/s41375-024-02390-9.
2. Ma MKF, et al. J Hepatol. 2017 Nov;67(5):979-990.
3. von Roemeling CA, et al. Oncotarget. 2017 Oct 6;9(1):3-20.
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