Catalog No.: PC-35639Not For Human Use, Lab Use Only.
STA-8666 (STA8666, STA-21-8666, PEN-866) is a novel HSP90 inhibitor/SN-38 drug conjugate (HDC), a potent topoisomerase I inhibitor and pharmacologically active metabolite of irinotecan, STA-8666 is cleaved by carboxylesterase (CES) to release SN-38.
STA-8666 (STA8666, STA-21-8666, PEN-866) is a novel HSP90 inhibitor/SN-38 drug conjugate (HDC), a potent topoisomerase I inhibitor and pharmacologically active metabolite of irinotecan, STA-8666 is cleaved by carboxylesterase (CES) to release SN-38.
STA-8666 demonstrates dramatically superior activity in comparison to equimolar doses of irinotecan against 5 patient-derived pancreatic adenocarcinoma xenografts with prolonged remissions in some tumors.
STA-8666 also causes complete tumor regression in preclinical mouse models of pediatric sarcoma.
