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Chemical Structure : STA-8666
Catalog No.: PC-35639Not For Human Use, Lab Use Only.
STA-8666 (STA8666, STA-21-8666, PEN-866) is a novel HSP90 inhibitor/SN-38 drug conjugate (HDC), a potent topoisomerase I inhibitor and pharmacologically active metabolite of irinotecan, STA-8666 is cleaved by carboxylesterase (CES) to release SN-38.
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STA-8666 (STA8666, STA-21-8666, PEN-866) is a novel HSP90 inhibitor/SN-38 drug conjugate (HDC), a potent topoisomerase I inhibitor and pharmacologically active metabolite of irinotecan, STA-8666 is cleaved by carboxylesterase (CES) to release SN-38.
STA-8666 demonstrates dramatically superior activity in comparison to equimolar doses of irinotecan against 5 patient-derived pancreatic adenocarcinoma xenografts with prolonged remissions in some tumors.
STA-8666 also causes complete tumor regression in preclinical mouse models of pediatric sarcoma.
| M.Wt | 879.971 | |
| Formula | C49H49N7O9 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Proia DA, et al. Mol Cancer Ther. 2015 Nov;14(11):2422-32.
2. Heske CM, et al. Oncotarget. 2016 Oct 4;7(40):65540-65552.
3. Bobrov E, et al. Oncotarget. 2017 Jan 17;8(3):4399-4409.
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