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STING agonist 1

Chemical Structure : STING agonist 1

CAS No.: 702662-50-8

STING agonist 1 (G10)

Catalog No.: PC-45676Not For Human Use, Lab Use Only.

G10 (STING Agonist 1) is a novel human-specific STING agonist; triggers IRF3/IFN-associated transcription in human fibroblasts.

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Biological Activity

G10 (STING Agonist 1) is a novel human-specific STING agonist; triggers IRF3/IFN-associated transcription in human fibroblasts.
G10 (STING Agonist 1) represenst the first synthetic small molecule characterized as an indirect activator of human STING-dependent phenotypes.
G10 (STING Agonist 1) inhibits CHIKV replication in vivo.

Physicochemical Properties

M.Wt 430.8797
Formula C21H16ClFN2O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2H-1,4-Benzothiazine-6-carboxamide, 4-[(2-chloro-6-fluorophenyl)methyl]-N-(2-furanylmethyl)-3,4-dihydro-3-oxo-

References

1. Sali TM, et al. PLoS Pathog. 2015 Dec 8;11(12):e1005324.

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