Catalog No.: PC-35784Not For Human Use, Lab Use Only.
STING agonist diABZI 3 is an amidobenzimidazole (ABZI)-based compound that functions as a potent, specific, non-nucleotide STING agonist, induces dose-dependent activation of STING and secretion of IFN-β with EC50 of 130 nM in human PBMCs.
STING agonist diABZI 3 is an amidobenzimidazole (ABZI)-based compound that functions as a potent, specific, non-nucleotide STING agonist, induces dose-dependent activation of STING and secretion of IFN-β with EC50 of 130 nM in human PBMCs.
STING agonist diABZI 3 is more than 400-fold more potent than cGAMP, also demonstrates high selectivity against >350 kinases.
STING agonist diABZI 3 activates secretion of IFNβ, IL-6, TNF, and KC/GROα (also known as CXCL1) in wild-type but not Sting−/− mice, induces STING-dependent activation of type-I interferon and pro-inflammatory cytokines in vivo via subcutaneous injection.
STING agonist diABZI 3 exhibits durable anti-tumour effect and causes complete tumour regression in syngeneic mouse model of colorectal tumours (CT-26) in BALB/c mice.
