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STX-213

Chemical Structure : STX-213

CAS No.: 415974-72-0

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STX-213 (STX213)

Catalog No.: PC-61430Not For Human Use, Lab Use Only.

An orally active, second-generation steroid sulfatase inhibitor with IC50 of 0.5 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

An orally active, second-generation steroid sulfatase inhibitor with IC50 of 0.5 nM; completely inhibits liver and tumor STS activity, and fully inhibits growth of MCF-7STS tumors in vivo.

Physicochemical Properties

M.Wt 420.524
Formula C21H28N2O5S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Sulfamic acid, (4aS,4bR,10bS,12aS)-1,2,3,4,4a,4b,5,6,10b,11,12,12a-dodecahydro-12a-methyl-1,3-dioxo-2-propylnaphth[2,1-f]isoquinolin-8-yl ester

References

1. Foster PA, et al. Clin Cancer Res. 2006 Sep 15;12(18):5543-9.

2. Foster PA, et al. Breast Cancer Res Treat. 2008 Sep;111(1):129-38.

3. Foster PA, et al. Endocrinology. 2008 Aug;149(8):4035-42.

4. Foster PA, et al. Clin Cancer Res. 2008 Oct 15;14(20):6469-77.

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