Chemical Structure : SZU-B6
CAS No.:
SZU-B6
Catalog No.: PC-23239Not For Human Use, Lab Use Only.
SZU-B6 is a highly potent and selective SIRT6 PROTAC degrader with DC50 of 45.29 nM and 154.28 nM in SK-HEP-1 and Huh-7 cells respectively.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
SZU-B6 is a highly potent and selective SIRT6 PROTAC degrader with DC50 of 45.29 nM and 154.28 nM in SK-HEP-1 and Huh-7 cells respectively.
Coincubation with the proteasome inhibitor MG132 completely disabled the SIRT6 degradation effect of SZU-B6. SZU-B6 exhibited inhibitory effects on the viability of SK-HEP-1 cells with IC50 of 1.51 uM, induced cell cycle arrest and apoptosis.
SZU-B is mediated through the recruitment of CRBN E3 ligase for SIRT6 polyubiquitination and proteasome-dependent proteolysis.
SZU-B6 exhibited significant synergistic effect in suppressing tumor growth in HCC xenografts when combined with the kinase inhibitor sorafenib or irradiation.
Physicochemical Properties
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M.Wt
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593.62
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Formula
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C29H32FN7O6
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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5-(4-((4-(3-Amino-4-nitrophenyl)piperazin-1-yl)methyl)piperidin-1-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione
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References
1. Huang J, et al. J Med Chem. 2024 Oct 10;67(19):17319-17349.
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