Chemical Structure : Seviteronel
CAS No.:
1610537-15-9
Seviteronel
(VT-464)
Catalog No.: PC-25060Not For Human Use, Lab Use Only.
Seviteronel (VT-464) is a potent, selective and oral inhibitor of CYP17A1 inhibitor with 17,20-lyase IC50 of 69 nM, 10-fold selective over 17α-hydroxylase.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Seviteronel (VT-464) is a potent, selective and oral inhibitor of CYP17A1 inhibitor with 17,20-lyase IC50 of 69 nM, 10-fold selective over 17α-hydroxylase.
Seviteronel (VT-464) demonstrated a greater decrease in AR transactivation compared with abiraterone (ABI).
Seviteronel (VT-464) suppressed the AR axis to a greater extent compared with ABI.
Seviteronel (VT-464) reduced AR signaling more effectively than abiraterone in cultured PCa cells expressing T877A AR mutant.
Seviteronel (VT-464) reduced the increase in tumor volume in castrate male mice of CRPC patient-derived xenograft, MDA-PCa-133 expressing H874Y AR mutant.
Physicochemical Properties
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M.Wt
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399.35
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Formula
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C18H17F4N3O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(S)-1-(6,7-bis(difluoromethoxy)naphthalen-2-yl)-2-methyl-1-(1H-1,2,3-triazol-5-yl)propan-1-ol
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References
1. Rafferty SW, et al. Bioorg Med Chem Lett. 2014 Jun 1;24(11):2444-7.
2. Toren PJ, et al. Mol Cancer Ther. 2015 Jan;14(1):59-69.
3. Maity SN, et al. Sci Rep. 2016 Oct 17;6:35354. doi: 10.1038/srep35354.
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