Catalog No.: PC-61529Not For Human Use, Lab Use Only.
T-226296 is a potent, selective, non-peptide antagonist of MCHR1 (Melanin-concentrating hormone receptor 1) with IC50 of 5.5 nM and 8.6 nM for human and rat MCHR1, respectively.
T-226296 is a potent, selective, non-peptide antagonist of MCHR1 (Melanin-concentrating hormone receptor 1) with IC50 of 5.5 nM and 8.6 nM for human and rat MCHR1, respectively.
T-226296 shows high selectivity over other receptors, including MCHR2.
T-226296 reverses the MCH-mediated inhibition of forskolin-stimulated cAMP accumulation, inhibits MCH-induced intracellular Ca2+ increase, and also inhibits MCH-stimulated arachidonic acid release in CHO cells.
T-226296 completely suppresses the food intake induced by MCH in rats (30mg/kg); orally active.
