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Chemical Structure : T-226296
Catalog No.: PC-61529Not For Human Use, Lab Use Only.
T-226296 is a potent, selective, non-peptide antagonist of MCHR1 (Melanin-concentrating hormone receptor 1) with IC50 of 5.5 nM and 8.6 nM for human and rat MCHR1, respectively.
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T-226296 is a potent, selective, non-peptide antagonist of MCHR1 (Melanin-concentrating hormone receptor 1) with IC50 of 5.5 nM and 8.6 nM for human and rat MCHR1, respectively.
T-226296 shows high selectivity over other receptors, including MCHR2.
T-226296 reverses the MCH-mediated inhibition of forskolin-stimulated cAMP accumulation, inhibits MCH-induced intracellular Ca2+ increase, and also inhibits MCH-stimulated arachidonic acid release in CHO cells.
T-226296 completely suppresses the food intake induced by MCH in rats (30mg/kg); orally active.
| M.Wt | 402.513 | |
| Formula | C26H27FN2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Takekawa S, et al. Eur J Pharmacol. 2002 Mar 8;438(3):129-35.
2. Basso AM, et al. Eur J Pharmacol. 2006 Jul 1;540(1-3):115-20.
3. Kowalski TJ, et al. Eur J Pharmacol. 2004 Aug 16;497(1):41-7.
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