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T-5224

Chemical Structure : T-5224

CAS No.: 530141-72-1

T-5224 (T5224;T 5224)

Catalog No.: PC-42934Not For Human Use, Lab Use Only.

T-5224 is a small molecule inhibitor of c-Fos/AP-1 that specifically inhibits the binding of AP-1 to the AP-1 binding site of the promoter region, attenuates the gelatinase activity of MMP-2 and -9.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

T-5224 is a small molecule inhibitor of c-Fos/AP-1 that specifically inhibits the binding of AP-1 to the AP-1 binding site of the promoter region, attenuates the gelatinase activity of MMP-2 and -9.
T-5224 inhibits the mRNA expression levels of MMP-1, 3, and 13, and IL-1β, TNF-α and IL-6 in IL-1-stimulated human chondrocytes, significantly inhibits the invasion, migration, and MMP activity of HNSCC cells, prevents lymph node metastasis in an oral cancer model.
T-5224 decreases the release of collagen selectively in SSc fibroblasts, prevents dermal fibrosis in vivo.

Physicochemical Properties

M.Wt 517.5266
Formula C29H27NO8
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 31 mg/mL

Chemical Name/SMILES

Benzenepropanoic acid, 5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(2,3-dihydro-3-oxo-1,2-benzisoxazol-6-yl)methoxy]-

References

1. Uchihashi S, et al. Drug Metab Dispos.

2. Avouac J, et al. Arthritis Rheum. 2012 May;64(5):1642-52.

3. Motomura H, et al. Biochem Biophys Res Commun. 2018 Mar 4;497(2):756-761.

4. Kamide D, et al. Cancer Sci. 2016 May;107(5):666-73.

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