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Chemical Structure : T-5224
CAS No.: 530141-72-1
Catalog No.: PC-42934Not For Human Use, Lab Use Only.
T-5224 is a small molecule inhibitor of c-Fos/AP-1 that specifically inhibits the binding of AP-1 to the AP-1 binding site of the promoter region, attenuates the gelatinase activity of MMP-2 and -9.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | Get quote |
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T-5224 is a small molecule inhibitor of c-Fos/AP-1 that specifically inhibits the binding of AP-1 to the AP-1 binding site of the promoter region, attenuates the gelatinase activity of MMP-2 and -9.
T-5224 inhibits the mRNA expression levels of MMP-1, 3, and 13, and IL-1β, TNF-α and IL-6 in IL-1-stimulated human chondrocytes, significantly inhibits the invasion, migration, and MMP activity of HNSCC cells, prevents lymph node metastasis in an oral cancer model.
T-5224 decreases the release of collagen selectively in SSc fibroblasts, prevents dermal fibrosis in vivo.
| M.Wt | 517.5266 | |
| Formula | C29H27NO8 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 31 mg/mL |
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| Chemical Name/SMILES |
Benzenepropanoic acid, 5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(2,3-dihydro-3-oxo-1,2-benzisoxazol-6-yl)methoxy]- |
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1. Uchihashi S, et al. Drug Metab Dispos.
2. Avouac J, et al. Arthritis Rheum. 2012 May;64(5):1642-52.
3. Motomura H, et al. Biochem Biophys Res Commun. 2018 Mar 4;497(2):756-761.
4. Kamide D, et al. Cancer Sci. 2016 May;107(5):666-73.
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